Search

Ethylene Oxide (EtO/EO)
Sterilization

Small-batch, quick-turn, in-house EtO sterilization delivers rapid processing in as little as 1-2 weeks standard (24 hour expedited) without compromising quality or compliance.

Current Available Capacity
0 %
Runs Completed
0 +
Full Validations Completed
0 +
Customers Served
0 +

Overcoming Today’s EtO Sterilization Challenges

While EtO sterilization is unmatched for its efficacy and compatibility with delicate medical devices, large-scale facilities face increased scrutiny and potential shutdowns due to stricter EPA regulations. LSO’s small-batch, canister-based, EtO sterilization not only bypasses these challenges but also reduces environmental impact and improves safety. This makes us a reliable alternative for medical device manufacturers seeking uninterrupted sterilization services.

What Is Ethylene Oxide (EtO) sterilization?

Small-batch canister-based EtO sterilization reduces exposure risks and environmental impact while retaining the efficacy and compatibility that make EtO the industry’s gold standard.

Ethylene Oxide (EtO) sterilization leverages a colorless gas that functions at relatively low temperatures. This approach currently stands out as the predominant sterilization technique for medical devices. Products are enclosed within a secure chamber where they are exposed to EtO gas. EtO inactivates microorganisms through alkylation of their molecular structures and genetic material. EtO has excellent compatibility with an array of materials, ranging from plastics and metals to glass.

Close-up of a gloved hand placing a sterilization canister into a 3M Steri-Vac GS8X system.
Technician assembling electronic components in a cleanroom environment with precise tools.

Who Is Using EtO?

Ethylene oxide sterilization is particularly effective for devices that are unable to tolerate high heat and radiation. It is widely used for pacemakers, delicate implants, surgical kits, syringes, and catheters. This method is beneficial for sterilizing a broad range of materials including plastic resins, metals, glass, and multi-layer packaging. As a surface sterilant, EtO is unable to travel past hermetic seals and gas-tight fittings.

How Does EtO Work?

At LSO, we utilize six (4 LSO West, 2 LSO East) in-house 3M™ In-House sterilizers with ‘All-In-One’ cycles. During the 1-8 hour (4 hour standard) customizable cycle times, pre-conditioning, sterilization, and aeration are performed in-chamber. Temperatures can range from 37-55 degrees C to suit different material requirements while meeting ISO 11135-2014 standards and conforming to all regulatory requirements (EPA OSHA, SCAQMD, AAMI) for quality and safety.

Why LSO?

In addition to our ‘always open’ capacity, we offer professional expertise with our in-house microbiologist, maintain the highest levels of compliance and certification, and have successfully assisted over 1,000 clients in processing numerous sterilization cycles and validations. With facilities on both coasts, we provide unparalleled access and support, ensuring faster turnaround times and flexibility for clients across the country. Building on this extensive experience, we streamline your sterilization process for ease and efficiency with:

  • Flexible Sterilization Cycles: From fractional to full cycles with EtO residual testing.
  • Robust Qualification: Secure with 2X qualification.
  • Choice of PCDs: Tailored to your sterilization needs.
  • Full EtO Validation: Comprehensive packages for regulatory compliance.
  • Routine Sterilization: Regular and reliable service.
  • Instrument Sterilization: In line with FDA guidelines.
  • Fast-Track Option: Expedited services for urgent projects.
  • Digital Documentation: Receive records quickly by fax or email.


We are committed to delivering end-to-end medical device sterilization and packaging support to our clients.

Full EtO Validation

Comprehensive packages for regulatory compliance.

Flexible Sterilization Cycles

From fractional to full cycles with EtO residual testing.

Robust Qualification

Secure with 2X qualification.

Choice of PCDs

Tailored to your sterilization needs.

Sign up for email resources!

Receive the latest infographics, guides, and blog updates for medical device manufacturing, package testing, and sterilization.